Abstract：Objective To investigate the effect of preemptive analgesia with ropivacaine mesylate and sufentanil on postoperative pain after radical surgery for ovarian cancer.Methods Twenty-four ovarian cancer patients(ASAⅠ-Ⅱ) who consented to undergo radical hysterectomy and pelvic lymphadenectomy were randomly divided into two groups,with 12 patients in each group.Patients in group A were given fractionated injection of 10 mL of 0.239% ropivacaine mesylate and 0.5 μg·kg-1 sufentanil mixture into the epidural space at 20 minutes before anaesthesia induction,and were treated with 10 mL epidural saline infusion at the time of peritoneal closure.Patients in group B were given 10 mL epidural saline infusion at 20 minutes before anaesthesia induction,and were treated with fractionated injection of 10 mL of 0.239% ropivacaine mesylate and 0.5 μg·kg-1 sufentanil mixture at the time of peritoneal closure.Postoperative recovery,analgesic effect and analgesic safety were observed in both groups.Results There were no significant differences in visual analog scale(VAS) scores at rest between the two groups at 4,8,12 and 24 hours after operation(P>0.05),but the VAS scores in group A were obviously lower than those in group B at 48 and 72 hours after operation(P<0.05).The differences in VAS scores at the time of postoperative cough were not significant between the two groups at 4 hours after operation(P>0.05),but the VAS scores in group A were obviously lower than those in group B at 8,12,24,48 and 72 hours after operation(P<0.05).The number of patient-controlled epidural analgesia(PCEA) button press and the amount of ropivacaine mesylate in group A were significantly lower than those in group B(all P<0.05).Times to eyes opening and extubation in group B were significantly longer than those in group A(P<0.05).There were no significant differences in the incidence of postoperative adverse events between the two groups(P>0.05).Conclusion Preemptive injection of 10 mL of 0.239% ropivacaine mesylate and 0.5μg/kg sufentanil mixture into the epidural space can effectively alleviate postoperative pain and the amount of analgesic drug use and has good analgesia efficacy and safety in patients undergoing radical surgery for ovarian cancer. 更多
黄健； 鲍希安； 周雪梅. 甲磺酸罗哌卡因和舒芬太尼超前镇痛对卵巢癌根治术术后疼痛的影响[J]. 南昌大学学报（医学版）, 2012, 52(06): 48-.
HUANG Jian,BAO Xi-an,ZHOU Xue-mei. Effect of Preemptive Analgesia with Ropivacaine Mesylate and Sufentanil on Postoperative Pain after Radical Surgery for Ovarian Cancer. , 2012, 52(06): 48-.
2012, Vol. 52 
