Abstract: Objective To determine the value of laparoscopic surgery combined with mifepristone(RU-486) in the treatment of unruptured cornual pregnancy.Methods Data of 27 patients treated for unruptured cornual pregnancy between January 2007 and December 2010 were retrospectively analyzed.The effects of laparoscopic surgery and laparoscopic surgery plus mifepristone on unruptured cornual pregnancy were compared.Results The success rate of laparoscopic surgery combined with mifepristone for the treatment of unruptured cornual pregnancy was 100%.Compared with laparoscopic surgery,the combination of laparoscopic surgery and mifepristone resulted in less blood loss,shorter duration of surgery and more efficient postoperative recovery.Conclusion Laparoscopic surgery combined with mifepristone is a safe and effective method to treat unruptured cornual pregnancy.