Abstract：Objective To observe the effect of combined therapy with fenofibrate and valsartan on blood pressure,serum lipids and insulin resistance in patients with primary hypertension and hypertriglyceridemia. Methods Fifty-five patients with primary hypertension and hypertriglyceridemia were divided into two groups.The treatment group(n=28) was treated with lipid-lowering diet and oral administration of 200 mg fenofibrate and 80 mg valsartan once per day for 2 months.The control group(n=27) was given lipid-lowering diet,placebo and oral administration of 80 mg valsartan once per day for 2 months.Changes in systolic blood pressure(SBP),diastolic blood pressure(DBP),triglyceride(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),fasting plasma glucose(FPG),fasting insulin(FINS) and insulin sensitivity index(ISI) were measured in both groups.Results In treatment group,levels of TC,TG,LDL-C,FPG and FINS significantly decreased and levels of HDL-C and ISI significantly decreased after 8 weeks of treatment(all P<0.05).However,the decrease in levels of TC,TG,LDL-C,FPG and FINS and the increase in levels of HDL-C and ISI were not obvious in control group after 8 weeks of treatment(all P>0.05).Conclusion The combined therapy with fenofibrate and valsartan can improve lipid profile and insulin resistance and regulate blood pressure to reduce the occurrence of cardiovascular events in patients with primary hypertension and hypertriglyceridemia.
王青； 况佩君. 非诺贝特联合缬沙坦治疗原发性高血压合并高三酰甘油血症的疗效[J]. 南昌大学学报（医学版）, 2012, 52(08): 44-.
WANG Qing,KUANG Pei-jun. Efficacy of Combined Therapy with Fenofibrate and Valsartan in Patients with Primary Hypertension and Hypertriglyceridemia. , 2012, 52(08): 44-.
2012, Vol. 52 
