Abstract：Objective To explore the effects of rhubarb on microinflammation state in non-uremic patients with chronic renal failure.Methods Sixty non-uremic outpatients and inpatients with chronic renal failure treated from Out-patients and Hospitallization of the Second Affiliated Hospital of Nanchang University and Jiangxi Province Tumor Hospital from January 2010 to March 2011 were randomly divided into treatment group and control group,with 30 patients in each group.All patients were routinely offered antihypertensive drugs,erythropoietin and heteropathy.In addition,patients in treatment group were additionally given rhubarb decoction(10 g once daily).Treatments were maintained for 2 weeks.Thirty healthy subjects from the Out-patients Department of Physical Examination of the Second Affiliated Hospital of Nanchang University were selected as normal controls.The levels of serum creatinine(Scr),amyloid A(SAA) and high sensitivity C-reative protein(hs-CRP) were detected before and after treatment,and creatinine clearance rate(Ccr) was calculated.Results No significant changes in levels of Scr and Ccr were found in patients after therapy(all P>0.05).Compared with normal controls,levels of SAA and hs-CRP obviously increased in patients before treatment(all P<0.05).Compared with values before treatment,levels of SAA and hs-CRP did not changed in control group(all P>0.05),but obviously decreased in treatment group after therapy(P<0.05).Furthermore,levels of SAA and hs-CRP in treatment group were significantly lower than those in control group after therapy(all P<0.05).There was a positive relationship between SAA levels and hs-CRP levels before treatment in non-uremic patients with chronic renal failure(r=0.866,P<0.05).Conclusion Microinflammation state exists in non-uremic patients with chronic renal failure and can be improved by rhubarb,which has no obvious influence on renal function.
2012, Vol. 52 
