Abstract： Objective To observe the clinical application of omeprazole in chemotherapy patients with advanced non-small cell lung cancer(NSCLC).Methods Sixty-seven patients with advanced NSCLC were randomly divided into two groups.All patients were treated with chemotherapy with combination of two platiniferous drugs.The control group(n=30) was given regular antiemetic drugs(ondansetrons,dexamethasone and metoclopramide,etc) on the first day of chemotherapy.The observation group(n= 37) was intravenously injected with 40 mg omeprazole(twice daily for 1-2 days and then once daily until 1-2 days after chemotherapy) after treatment with regular antiemetic drugs.Gastrointestinal reaction and the number of chemotherapy courses were compared between the two groups.Results The total effective rate was 89.2% for nausea and 75.7% for vomiting in observation group,and 66.7% for nausea and 63.3% for vomiting in control group.The differences between the two groups were statistically significant(P<0.05).In addition,the number of chemotherapy courses in observation group was more than that in control group(P<0.05).Conclusion Omeprazole plays a role in preventing chemotherapy-induced gastrointestinal reaction and may have antitumor activity against chemotherapy-resistant NSCLC.
2011, Vol. 53 
