Abstract： Objective To evaluate the value of 3.0T magnetic resonance diffusion-weighted imaging(DWI) in differentiating the malignant from benign pulmonary masses.Methods Fifty-six patients with CT and resection proved peripheral lung tumors underwent MRI and DWI(b value:0,300,500,700 and 900 s·mm-2),and different ADCs were generated.Signal intensity on DWI images was scored by 5-point method with comparison to thoracic and chest wall muscles,and the sensitivity and specificity of DWI were used to evaluate the characteristics of masses by analyzing t test and ROC curve.The quantitative ADC was obtained corresponding to the specific regions of interest with different b values.Results The mean score of malignant pulmonary tumors(3.97±1.21)was significantly higher than that of benign nodules(2.55±1.46)when thoracic muscle was used as reference(P=0.000 36).Lesions with intensity greater than or equal to the reference were judged as lung cancer,and the diagnostic sensitivity and specificity were 86.8% and 66.7%,respectively.The mean score of malignant pulmonary tumors(4.23±0.99)was significantly higher than that of benign nodules(2.94±1.43)when spinal cord was used as reference(P=0.000 25).Lesions with intensity greater than or equal to the reference were judged as lung cancer,and the diagnostic sensitivity and specificity were 94.7% and 50.0%,respectively.The diagnostic ability of chest wall muscle as reference with the area under ROC curve(0.768) was a little better than that of spinal cord as reference with the area under ROC curve(0.729)(P>0.05).There was no statistical significance between lung cancer and inflammation of varying b values in ADC maps.Conclusion Signal intensity on 3.0T magnetic resonance DWI images is helpful for the differential diagnosis between the benign and malignant lung lesions.The chest wall muscle as a reference has high diagnostic sensitivity and specificity.ADC values can not be used as the quantitative standards for differential diagnosis in lung diseases.DWI may be a potential assistive technology for differential diagnosis of pulmonary neoplasms.
王敏君； 张伟； 张宁； 彭德昌； 李五根； 李朸； 肖香佐. 3.0T磁共振扩散加权成像对肺部良恶性肿块的诊断价值[J]. 南昌大学学报（医学版）, 2011, 53(11): 14-19.
WANG Min-jun a,ZHANG Wei b,ZHANG Ning a, PENG De-chang a,LI Wu-gen a,LI Li a,XIAO Xiang-zuo a. Diagnostic Value of 3.0T Magnetic Resonance Diffusion-weighted Imaging in Benign and Malignant Lung Tumors. , 2011, 53(11): 14-19.
2011, Vol. 53 
