Diagnostic Values of Free/Total(F/T) Prostate-specific Antigen(PSA)Ratio,PSA Transition Zone Density and(F/T)/PSA Density in Prostate Cancer in Patients with Gray Zone PSA
Abstract：Objective To evaluate the diagnostic values of free/total(F/T) prostate-specific antigen(PSA) ratio(FPSA/TPSA),PSA transition zone density(PSATZ) and(F/T)/PSA Density [(F/T)/PSAD] in prostate cancer in patients with gray zone PSA.Methods A retrospective analysis was performed in 62 patients with serum PSA 4 to 10 ng·mL-1(20 prostate cancer patients and 42 benign prostatic hyperplasia patients) who were treated in the department of urinary surgery of the first affiliated hospital of Nanchang university between January 2007 and October 2010.Concentrations of TPSA and FPSA were detected by time-resolved fluoroimmunoassay.Prostate volume and transition zone volume were measured by transrectal ultrasound.Then FPSA/TPSA,PSATZ and(F/T)/PSAD were calculated with the formula.Results There were no obvious differences in TPSA between prostate cancer group and benign prostatic hyperplasia group [(6.670±1.780)ng·mL-1vs(5.937±1.411) ng·mL-1,P>0.05].However,differences in FPSA/TPSA,PSATZ and(F/T)/PSAD were significantly different between the two groups [(0.122±0.058),(0.592±0.255)ng-1·mL-1·cc-1 and(0.437±0.449) vs(0.185±0.078),(0.285±0.184)ng-1·mL-1·cc-1and(1.822±1.527),respectively;P<0.01].The descending order of the values of the area under ROC curve was(F/T)/PSAD,PSATZ,FPSA/TPSA ratio and TPSA.Conclusion FPSA/TPSA,PSATZ and(F/T)/PSAD,especially PSATZ and(F/T)/PSAD,offer an improvement in the diagnosis of prostate cancer in patients with serum PSA 4 to 10 ng·mL-1.
翟元憬；陈卫民；文丽生；夏初霞；张健平；毛亚南. FPSA/TPSA、PSATZ、(F/T)/PSAD对PSA灰值区前列腺癌的诊断价值[J]. 南昌大学学报（医学版）, 2012, 5(07): 25-.
ZHAI Yuan-jing1a,CHEN Wei-min2a,WEN Li-sheng2b,XIA Chu-xia1b, ZHANG Jian-ping1a,MAO Ya-nan1a. Diagnostic Values of Free/Total(F/T) Prostate-specific Antigen(PSA)Ratio,PSA Transition Zone Density and(F/T)/PSA Density in Prostate Cancer in Patients with Gray Zone PSA. , 2012, 5(07): 25-.
2012, Vol. 5 
