Abstract：Objective To explore the independent risk factors for coronary artery disease(CAD) through investigating the relationships of carotid intima-media thickness(CIMT),paque scores and high-sensitivity C-reactive potein(hs-CRP) levels to coronary heart disease,and to determine the best predictive values of CIMT and hs-CRP levels by using the receiver operating characteristic(ROC) curve.Methods Color Doppler ultrasound of bilateral carotid arteries was performed to measure CIMT and paque scores in 87 patients with coronary angiography confirmed CAD(CAD group) and 29 healthy subjects(control group).The levels of serum hs-CRP,blood glucose and blood lipids were determined and the history of diabetes,smoking and hypertension was recorded.Results Compared with control group,CIMT,paque scores and serum hs-CRP levels significantly increased in CAD group(P<0.001).Multiple logistic regression analysis showed that CIMT and hs-CRP were the independent risk factors for CAD.The cutoff levels obtained from ROC curves were 0.78 mm for CIMT(sensitivity 96.6%,specificity 41.0%) and 2.15 mg·L-1 for hs-CRP(sensitivity 85.1%,specificity 72.3%).The CIMT was significantly correlated with diabetes,smoking and hypertension history and blood total cholesterol(TC) levels.The levels of serum hs-CRP were significantly correlated with diabetes and hypertension.Conclusion The history of diabetes,smoking and levels of TC are the risk factors for CIMT.The hypertension and diabetes are the risk factors for hs-CRP.The CIMT and hs-CRP are the independent risk factors for predicting CAD.
2012, Vol. 52 
