Abstract：Objective To investigate the value of Netrin-1 for the early detection of acute kidney injury(AKI).Methods The AKI was induced in 40 SD rats by ischemia-reperfusion(ischemia-reperfusion group,n=10),folic acid(folic acid,n=10),lipopolysaccharide(LPS group,n=10) and cisplatin(cisplatin group,n=10),respectively.The levels of urine Netrin-1 and serum creatinine were measured 1,3,6,24,48 and 72 hours after treatment.Results The levels of urine Netrin-1 significantly increased 20-fold 3 hours after renal ischemia-reperfusion relative to baseline(P<0.01),reached the peak after 6 hours,and then slowly decreased to normal levels after 48 hours.However,serum creatinine concentrations significantly increased up to peak 24 hours after reperfusion.In rats treated with cisplatin,folic acid or LPS,urine Netrin-1 levels increased 1 hour after induction,peaked 6,3,6 hours after injury.But,serum creatinine concentrations significantly increased after 24,6,6 hours(all P<0.01).Conclusion Urinary Netrin-1 is a promising biomarker for early detection of renal injury.
陈玉； 蔡利励； 郑剑锋； 王小中. 神经导向因子-1在急性肾损伤模型大鼠尿液中的含量变化[J]. 南昌大学学报（医学版）, 2012, 52(02): 11-.
CHEN Yu,Cai Li-li,ZHENG Jian-feng,WANG Xiao-zhong. Changes in Urine Netrin-1 and Its Application in Rat Model of Acute Kidney Injury. , 2012, 52(02): 11-.
2012, Vol. 52 
