Abstract： Objective To evaluate the efficacy of chemotherapy in conjunction with three-dimensional conformal hyperfractionated radiotherapy in the treatment of limited-stage small-cell lung cancer(SCLC).Methods Sixty patients with limited-stage SCLC were randomly assigned to receive either concurrent chemoradiotherapy(C group,n=30) or sequential chemoradiotherapy(S group,n=30).All patients were treated with 4-6 cycles of EP scheme(VP-16 75 mg·m-2·d-1,d1-d5+DDP 80 mg·m-2·d-1,d1).Radiation was delivered with a three-dimensional conformal hyperfractionated technique using 6MV-X ray(1.5 Gy twice daily,equal to 45 Gy in 15 days continuously).Three-dimensional conformal hyperfractionated radiotherapy was performed from the first day of chemotherapy and after the fourth chemotherapy cycle in the C group and S group,respectively.Patients achieved complete remission(CR) were given prophylactic cranial irradiation(PCI).Results The CR rate was 46.7% and 16.7%(P=0.025) and total effective rate was 83.3% and 53.3%(P=0.013) in C group and S group,respectively.There were no significant differences in adverse reactions between the two groups(P>0.05).The 1-3-year survival rates in C group(86.7%,63.3% and 30.0%,respectively) were obviously higher than those in S group(73.3%,30.0% and 16.7%,respectively)(P=0.035).Local recurrence rate was 16.7% and 40.0%(P=0.047) and distant metastasis rate was 36.7% and 66.7%(P=0.038) in C group and S group,respectively.Conclusion The chemotherapy in conjunction with three-dimensional conformal hyperfractionated radiotherapy can significantly increase CR rate and survival rate in patients with limited-stage SCLC.
2011, Vol. 53 
