Abstract： Objective To explore the effect of cholecystokinin octapeptide on recovery after sciatic nerve injury in rats.Methods A model of sciatic nerve injury was established in 24 rats.These rats were assigned to receive intraperitoneal injection of either 1 nmol·kg-1 of cholecystokinin octapeptide(experiment group,n=12) or 8 nmol·kg-1 of isotonic saline(control grup,n=12) for 7 days.Compound nerve action potential(CNAP) and sensory nerve action potential(SNAP) of sciatic nerves and compound muscle action potential(CMAP) of gastrocnemius muscles were detected by an electromyography recorder postoperative 4 weeks.The latency(LAT),amplitude(AMP) and nerve conduction velocity(NCV) were recorded.Results Postoperative 4 week,LAT difference values of CNAP,SNAP and CMAP and recovery rates of AMP and NCV in experiment group were significantly different from those in control group(P<0.05 or P<0.01).The gastrocnemius electromyography of volatility high and incubation period short in experiment group.Conclusion Cholecystokinin octapeptide can promote the recovery after peripheral nerves.
2012, Vol. 5 
