Abstract：Objective To investigate the inhibitive effect of recombinant human endostatin(rHES) on corneal neovascularization(CNV) induced by suture.Methods Corneal neovascularization was induced by stitching cornea in 24 New Zealand white rabbits.These rabbits were randomly divided into three groups,with 8 rabbits in each group.Rabbits in group A,B and C were sub-conjunctivally injected with 0.1 mL normal saline,0.1 mL rHES and 0.1 mL dexamethasone(0.5 mg) every other day,respectively.The area of neovascularization was calculated by measuring vessel length of corneal neovascularization under slit-lamp illumination.The study lasted 3 weeks.Results Compared with group A,the vessel length and area of corneal neovascularization significantly decreased in group B and group C at each time point(P<0.001).Compared with group B,the vessel length and area of corneal neovascularization obviously increased in group C on the thirteenth and eighteenth day(P<0.05).Conclusion The rHES can effectively inhibit corneal neovascularization.
引用本文:
钟敏；何建中；李荣；罗荣城. 重组人血管内皮抑制素抑制角膜新生血管的实验研究[J]. 南昌大学学报（医学版）, 2012, 52(05): 28-.
ZHONG Min1,2,HE Jian-zhong2,LI Rong1,LUO Rong-cheng1. Inhibitive Effect of Recombinant Human Endostatin on Corneal Neovascularization. , 2012, 52(05): 28-.
2012, Vol. 52 
