Abstract：Objective To compare the results of microalbuminuria(MAU) determination with automatic chemistry analyzer under different analytical conditions.Methods The same specimens were used for MAU determination with a Hitachi automatic chemistry analyzer according to CLSI EP9-A2 and EP7-A2 by three detection methods:1) the random analysis of blood and urine samples in a same batch;2) the separate batch analysis of urine samples;3) the same batch analysis of blood samples by inserting urine samples.The data were statistically analyzed.Results Results achieved by method 1 were significantly different from the specific protein analysis data(P<0.001,r=0.968 2,bias=40.9),but there were no obvious differences in results between method 2 and specific protein analysis(P>0.05,r=0.998 9,bias=0.8).Results achieved by method 3 showed serious cross-contamination in serum specimens(maximum contamination rate,341.3%).Conclusion According to medical decision level,CLIA’88(2003) and EP7-A2,method 1 for MAU determination may mislead clinical diagnosis and treatment;method 2 for MAU determination may interfere with subsequent detection;method 3 for MAU determination can meet the requirements of clinical application.
引用本文:
熊声贺； 樊斌； 黄新城. 日立生化分析仪检测尿微量白蛋白结果评价与分析条件[J]. 南昌大学学报（医学版）, 2012, 52(06): 76-.
XIONG Sheng-he,FAN Bin,HUANG Xin-cheng. Result Evaluation and Analytical Conditions of Microalbuminuria Determination by Hitachi Automatic Chemistry Analyzer. , 2012, 52(06): 76-.
2012, Vol. 52 
