Abstract: Objective To explore the relationship of blood zinc(Zn2+),iron(Fe2+) and lead(Pb2+) levels to rickets in infants and preschool children.Methods The levels of Zn2+and Fe2+were measured by atomic absorption spectrometer and levels of Pb2+were detected by atomic absorption spectrometer using tungsten boat furnace-sample in 216 rickets children who were randomly selected from child health clinics of maternal and child health hospital of Jiangxi province between September 2006 and June 2008(study group).During the same period,200 health children were chosen as the healthy control group.Results Rickets children had significantly lower blood Zn2+and Fe2+ levels and obviously higher blood Pb2+ levels than healthy control children(all P<0.01).Compared with healthy control group,the detection rates of Zn and Fe deficiencies and Pb poisoning significantly increased in study group(all P<0.01). Conclusion Trace elements should be determined in infants and preschool children with rickets for early detection and treatment of Zn and Fe deficiencies and Pb poisoning to enhance therapeutic efficacy in rickets.