Abstract： Objective To study the expression of caveolin-1 and vascular endothelial growth factor(VEGF) in normal cervix,chronic cervicitis,cervical intraepithelial neoplasia(CIN) and invasive cervical cancer,and to investigate the relationships of Caveolin-1 to VEGF and clinical-pathologic characteristics of Cervical cancer.Methods The expression of Caveolin-1 and VEGF was detected by immunohistochemical staining using streptavidin-biotin peroxidase technology in 30 normal cervical specimens,40 chronic cervicitis,30 CINⅠ-Ⅱ specimens,20 CINⅢ specimens,and 40 invasive cervical cancer specimens(21 stage Ⅰ specimens and 19 stage Ⅱ specimens).Results The positive expression rate of caveolin-1 was 100.00%(30/30),95.00%(38/40),83.33%(25/30),75.00%(15/20) and 72.50%(29/40)in normal cervix,chronic cervicitis,CINⅠ-Ⅱ,CINⅢ and invasive cervical cancer,respectively(P<0.05).The positive expression rate of VEGF was 10.00%(3/30),15.00%(6/40),26.67%(8/30),45.00%(9/20)and 90.00%(36/40)in normal cervix,chronic cervicitis,CINⅠ-Ⅱ,CINⅢ and invasive cervical cancer,respectively(P<0.05).The expression of caveolin-1 and VEGF in cervical carcinoma was not correlated with age and TNM stage(P>0.05),but was significantly correlated with pathological grade,invasion depth and regional lymph node metastasis(P<0.05).The expression of caveolin-1,but not VEGF,was correlated with tumor volume(P<0.05).There was a negative correlation between caveolin-1 protein expression and VEGF protein expression in cervical careinoma and CINⅢ(column connection number C was 0.498 or 0.538,P<0.05).Conclusion The expression of caveolin-1 and VEGF is an early event in cervical tumorigenesis,and caveolin-1 and VEGF may exert opposite effects on tumorigenesis,cancer development and angiogenesis.
王文华； 陈春林； 刘萍. Caveolin-1在子宫颈癌及上皮内瘤中的表达及其与VEGF的关系[J]. 南昌大学学报（医学版）, 2012, 52(06): 26-.
WANG Wen-hua1,2,CHEN Chun-lin1,LIU Ping1. Expression of Caveolin-1 in Cervical Cancer and Intraepithelial Neoplasia and Its Relationship with Vascular Endothelial Growth Factor. , 2012, 52(06): 26-.
2012, Vol. 52 
