Abstract:Objective To investigate the role of mycoplasma infection in recurrent vulvovaginal candidiasis(RVVC) through the detection and treatment of mycoplasma.Methods Data of 250 patients diagnosed with RVVC in past 3 years were retrospectively analyzed.Theses patients were randomly divided into two groups.Patients in experimental group(n=100) underwent mycoplasma detection and drug susceptibility testing,and then mycoplasma positive RVVC patients were given conventional anti-fungal and anti-mycoplasma treatment and mycoplasma negative RVVC patients were only given anti-fungal treatment.The control group(n=150) only received conventional anti-fungal therapy.Results Among the 100 patients in experimental group,RVVC was complicated by mycoplasma infection in 69(69%),and clinical cure was achieved in 64(92.75%).Among mycoplasma negative RVVC patients,clinical cure was achieved in 28(90.32%).Among the 150 patients in control group,clinical cure was achieved in 61(40.67%).Experiment 1 and 2 compared with the control group the cure rate difference was statistically sigaificant(P<0.01).Conclusion Mycoplasma infection can induce RVVC.Simultaneous treatment of mycoplasma infection and RVVC can reduce recurrence of RVVC.