Abstract：Classical swine fever virus can persistently infect swine for its ability to escape the killing of immune system.In order to prove it,Newcastle disease virus as IFN inducer,firefly luciferase reporter system was used to test the effect on interferon-beta promoter induced by CSFV Shimen strain.Results demonstrate that CSFV can’t induce IFN-βpromoter but can obviously inhibit the NDV-mediated-activation,which prove that CSFV escape from the killing of immune system by inhibiting IFN production.The research partly explains why CSFV can establish persistent infection in swine.
2012, Vol. 36 
