Abstract：Objective To observe the changes in thyroid volume and haemodynamics before and after Ⅰ-131 treatment of Graves’ disease(GD),and to evaluate the diagnostic value of color Doppler ultrasonography in GD.Methods Thyroid volume was measured by two-dimensional ultrasonography in 52 patients with GD who had been clinically cured with Ⅰ-131 at 1 day before treatment and 6 months after treatment.Furthermore,inner diameter of superior thyroid artery,peak systolic velocity(PSV),end-diastolic velocity(EDV) and resistance index(RI) were determined by color Doppler ultrasonography.Results Compared with values before treatment,I-131 treatment induced significant increase in RI(0.64±0.13 vs 0.49±0.09,P<0.05),but obvious decrease in thyroid volume,inner diameter of superior thyroid artery,PSV and EDV[(11.98±6.52)cm3,(0.19±0.08)cm,(64.7±24.6)cm·s-1 and(26.4±11.6)cm·s-1vs(15.36±6.69)cm3,(0.22±0.05)cm,(123±37.6)cm·s-1 and(59.1±18.7)cm·s-1,respectively;P<0.05 or P<0.01)].Moreover,the proportions of patients with blood flow grade Ⅰ and Ⅱ before treatment were significantly lower than those after treatment(1.92% and 17.31% vs 59.62% and 26.92%,respectively;P<0.05 or P<0.01),but the proportion of patients with blood flow grade Ⅲ before treatment was markedly higher than that after treatment(80.77% vs 13.46%,P<0.01).Conclusion The determination of thyroid volume and hemodynamics with color Doppler ultrasonography before and after Ⅰ-131 treatment has important clinical values for the diagnosis and treatment of GD.
2012, Vol. 52 
