Abstract： Objective To evaluate the curative effect and safety of Bifidobacterium capsules in patients with constipation-predominant irritable bowel syndrome.Methods Fifty cases of constipation-predominant irritable bowel syndrome were treated with oral Bifidobacterium capsules(0.7 g) three times per day(two capsules each time) for 28 days.The symptom improvement,curative effect,adverse reactions were observed in all patients.Results Among the 50 patients,complete cure was achieved in 8 and Bifidobacterium treatment was markedly effective in 28,effective in 10 and ineffective in 4 patients,with a total effective rate was 92.0%.After treatment with Bifidobacterium capsules,occurrence time of abdominal pain,frequency of abdominal pain,abdominal pain during defecation,abdominal distention and abnormal defecation trait ratio,rate of abnormal defecation number decreased significantly(P<0.05).During treatment with Bifidobacterium capsules,diarrhea occurred in 1 patient and fever in 1 patient.These two symptoms were not related to Bifidobacterium capsules through detailed history inquiry and other auxiliary examinations.Conclusion Bifidobacterium can effectively improve clinical symptoms of constipation-predominant irritable bowel syndrome with good safety and tolerability features.
2011, Vol. 53 
