Abstract：Objective To investigate the clinical and pathological features of IgA nephropathy with or without renal deposition of hepatitis B virus(HBV) antigens,and to explore the relationship between IgA nephropathy and HBV infection.Methods A total of 316 patients with IgA nephropathy confirmed by renal biopsy at Peking University Shenzhen Hospital from December 2008 to December 2011 were selected in this study,including 25 patients with glomerular deposition of HBsAg and/or HBcAg(study group) and 291 patients without HBsAg and/or HBcAg deposition(control group).Renal biopsy specimens were examined by optical microscopy,immunofluorescence and electron microscopy.Serum HBV markers,creatinine,cholesterol,albumin,C3,IgA and 24-hour urinary protein excretion were detected,and scores of glomerular active lesions,glomerular chronic lesions and tubulo-interstitial lesions were measured in both groups.Results There were no significant differences in scores of glomerular active lesions and glomerular chronic lesions between the two groups(all P>0.05).But scores of tubulo-interstitial lesion and positive rates of HBV infection in study group were significantly higher than those in control group(P<0.05 or P<0.01).Furthermore,the study group had a slightly higher levels of C1q deposition than control group,but the difference was not statistically significant(P>0.05).Conclusion Renal deposition of HBV antigens is not correlated with IgA nephropathy,but may aggravate tubulo-interstitial damage.
熊子波；梁伟；郑爱萍；熊祖应；贺丽娟；罗琼. 伴有与无肾组织乙肝病毒抗原沉积的IgA肾病患者临床和病理对比分析[J]. 南昌大学学报（医学版）, 2012, 52(05): 48-.
XIONG Zi-boa,LIANG Weia,ZHENG Ai-pingb,XIONG Zu-yinga,HE Li-juana,LUO Qionga . Comparison of Clinical and Pathological Features in IgA Nephropathy Patients with and without Renal Deposition of Hepatitis B Virus Antigens. , 2012, 52(05): 48-.
2012, Vol. 52 
