Abstract：Objective To investigate the relationship between estrogen receptor alpha(ERα) gene TA repeat polymorphism and bone mineral density(BMD) in postmenopausal women in Nanchang city.Methods A total of 100 postmenopausal women in Nanchang were selected according to the requirement for investigation and were divided into osteoporosis group(n=40) and non-osteoporosis group(n=60).Basic data of subjects were collected.The BMD was measured by dual energy X-ray absorptiometry and TA repeat sequence polymorphism was detected by sequencing.Results TA12 allele frequency in osteoporosis group was significantly lower than that in non-osteoporosis group(7.50% vs 26.67%,P=0.019).Conclusion TA12 allele may be the protective gene in osteoporosis.
陈宗玮； 彭维杰； 周颖； 刘永飞； 罗丹. 雌激素受体α基因TA重复序列多态性与南昌市绝经后妇女骨密度的相关性研究[J]. 南昌大学学报（医学版）, 2012, 52(05): 1-.
CHEN Zong-wei1,2,PENG Wei-jie1,ZHOU Ying1,LIU Yong-fei1,LUO Dan1. Relationship between ERα Gene TA Repeat Sequence Polymorphism and Bone Mineral Density in Postmenopausal Women in Nanchang City. , 2012, 52(05): 1-.
2012, Vol. 52 
