Abstract： Objective To investigate the expression of CXCL2 and HIF-1α in prostate cancer(PC) tissue,and to analyze its relationship to clinical and pathological features of PC.Methods The expression of CXCL2 and HIF-1α was detected by immunohistochemistry in 112 prostate specimens,including 76 PC specimens(PC group),15 prostatic intraepithelial neoplasia(PIN) specimens(PIN group) and 21 benign prostatic hyperplasia(BPH) specimens(BPH group).Results Compared with PIN group,the positive expression rates of CXCL2 and HIF-1α significantly increased in PC group,but obviously decreased in BPH group(P<0.01).Compared with mod-erately differentiated tissue,the expression of CXCL2 and HIF-1α significantly increased in poorly differentiated tissue,but obviously decreased in well-differentiated tissue(P<0.01).CXCL2 expression in A and B stage groups was lower than that in C stage group(P<0.05or P<0.01).CXCL2 expression in A,B and C stage groups was lower than that in D stage group(P<0.01).HIF-1αexpression in A,B and C stage groups was lower than that in D stage group(P<0.05or P<0.01).HIF-1α expression in A stage group was lower than that in B and C stage groups(P<0.05 or P<0.01).HIF-1α expression in B stage group was lower than that in C stage group(P<0.05).Furthermore,the expression of CXCL2 and HIF-1α in metastatic PC was significantly higher than that in non-metastatic PC(P<0.01).There was a positive correlation between CXCL2expression and HIF-1α expression(r=0.422,P<0.01).Conclusion Both CXCL2 and HIF-1α are highly expressed in PC tissue,and the expression is correlated with pathological grade,clinical stage and lymph node metastasis.But,the action mechanism of CXCL2 and HIF-1α in PC occurrence and development remains to be further investigated.
刘页玲； 朱清仙. CXCL2、HIF-1α在前列腺癌组织中的表达及意义[J]. 南昌大学学报（医学版）, 2012, 52(04): 41-.
LIU Ye-ling 1,2a,ZHU Qing-xian 2b. Expression and Significance of CXCL2 and HIF-1α in Prostate Cancer Tissue. , 2012, 52(04): 41-.
2012, Vol. 52 
