Clinical Significance of Alkaline Phosphatase,γ-Glutamyl Transpeptidase and Cholinesterase Detection in Chronic Hepatitis B,Liver Cirrhosis,Hepatocellular Carcinoma and Biliary Tract Disease
Abstract：Objective To investigate the clinical significance of alkaline phosphatase(ALP),γ-glutamyl transpeptidase(γ-GT) and cholinesterase(CHE) detection for the diagnosis of chronic hepatitis B,liver cirrhosis,liver cancer and biliary tract disease.Methods A retrospective analysis was performed in 295 patients treated between March 2008 and December 2010,including 78 patients with chronic hepatitis B,74 patients with liver cirrhosis,71 patients with primary hepatocellular carcinoma,and 72 patients with biliary tract disease(cholecystitis and cholelithiasis).The levels of serum ALP,γ-GT and CHE were detected in these patients and 51 healthy control subjects.Results The levels of ALP and γ-GT in patients were significantly higher than those in control subjects(P<0.001 or P<0.01).Furthermore,ALP and γ-GT levels in patients with primary hepatocellular carcinoma were significantly higher than those in others.Compared with control subjects,CHE levels obviously decreased in patients with liver cirrhosis or primary hepatocellular carcinoma(P<0.001),but did not changed in patients with chronic hepatitis B or biliary tract disease(P>0.05).Conclusion The levels of ALP,γ-GT and CHE are different among patients with chronic hepatitis B,liver cirrhosis,primary hepatic carcinoma and biliary tract disease.The determination of ALP and γ-GT can help to diagnose chronic hepatitis B,liver cirrhosis,primary hepatocellular carcinoma and biliary tract disease.The detection of CHE may contribute to the diagnosis of liver cirrhosis and primary hepatocellular carcinoma,and can be used to assess the disease severity and prognosis.
2012, Vol. 52 
