Abstract：Objective To observe the effect of compound traditional Chinese medicine Kuhuang decoction on acute rejection(AR) after orthotropic liver transplantation(OLT) in rats.Methods The model of OLT was established in 80 rats(Wistar donors and recipients).Liver recipients were,respectively,administered intragastrically with 2 mL·d-1normal saline(group A),2 mL·d-1 Kuhung decoction(group B),10 mg·kg-1·d-1cyclosporine A(group C) and 1 mL·d-1 Kuhuang decoction plus 5 mg·kg-1·d-1cyclosporine A(group D) from 1 day before operation to 1 month after operation once per day.Ten recipients in each group were sacrificed on postoperative day 7.Liver tissue was collected to observe the intensity of acute rejection and vena cava blood was taken to measure the levels of aspartate aminotransferase(AST) and alanine aminotransferase(ALT).The remaining rats were fed to record the survival time.Results Compared with group A,mean survival time significantly increased,and AST,ALT and rejection activity index obviously decreased in other groups(all P<0.05),especially in group D.Conclusion Compound traditional Chinese medicine Kuhuang decoction can inhibit acute rejection after OLT and has a synergistic effect with cyclosporine A.
吴勤荣;时军;罗文峰;徐志丹;李新长;丁利民. 复方中药(苦黄汤)对大鼠原位肝移植急性排斥反应的影响[J]. 南昌大学学报（医学版）, 2012, 52(02): 6-.
WU Qin-rong1,2,SHI JUN1,LUO Wen-feng1,XU Zhi-dan1,LI Xin-chang1,DING Li-min1. Effect of Compound Traditional Chinese Medicine Kuhuang Decoction on Acute Rejection after Orthotopic Liver Transplantation in Rats. , 2012, 52(02): 6-.
2012, Vol. 52 
