Abstract： Objective To investigate the pharmacokinetic behavior of ginsenoside Rg1 and Rb1 after intragastric administration of Fufang Xueshuantong tablets in rats.Methods The LC-MS was established to determine the blood drug concentrations of ginsenoside Rg1 and Rb1 after intragastric administration of Fufang Xueshuantong tablets(1 200 mg·kg-1) in 8 rats.Statistical analysis of pharmacokinetic data was carried out by DAS.Results After intragastric administration of Fufang Xueshuantong tablets,plasma concentrations of ginsenoside Rg1 and Rb1 reached maximum values quickly(1.02 h,1.05 h).The absorption of Rg1 was poorer and the bioavailability was lower as compared to Rb1.Moreover,the half life of Rb1 was longer than that of Rg1 [(16.45±3.17) hours vs(4.33±1.34) hours].Conclusion The pharmacokinetic behavior of ginsenoside Rg1 and Rb1 in Fufang Xueshuantong tablets has positive significance in the study of new drugs and preparations containing ginsenoside Rg1 and Rb1.
2011, Vol. 53 
