Abstract： Objective To investigate the protective effects of vitamin C and taurine on iron overload cardiomyopathy in mice.Methods A mouse model of myocardial iron overload was made by intraperitoneal injection of dextroglucose chalybeate.Iron-overloaded mice were intragastricly administrated with 150 mg·kg-1vitamin C(Asc group),420 mg·kg-1 taurine(Tau group),75 mg·kg-1 vitamin C plus 210 mg·kg-1 taurine(Asc+Tau group) or 0.5 mL normal saline(iron overload group).Control mice received 0.5 mL normal saline only.The plasma creatine kinase(CK) and lactate dehydrogenase(LDH) activities were detected and myocardial malondialdehye(MDA) content and superoxide dismutase(SOD) and glutathione peroxidase(GSH-PX) activities were measured in all mice.Results Plasma CK activities and myocardial MDA concentrations in Asc group,Tau group and Asc+Tau group significantly decreased compared with iron overload group(P<0.05),but obviously increased compared with control group(P<0.05).Moreover,vitamin C and taurine had a synergistic effect(P<0.05).Plasma LDH activities in iron overload group were significantly higher than those in other groups(P<0.05),but no differences were observed among other four groups(P>0.05).Compared with iron overload group,plasma SOD activities significantly increased in Tau group,Asc+Tau group and control group(P<0.05),but there were no differences among the three groups(P>0.05).Conclusion Vitamin C has a protective effect on myocardial damage induced by iron overload.In addition,vitamin C can synergize with taurine to improve iron overload cardiomyopathy in mice.
2011, Vol. 53 
